In vivo models
Amylgen designed these models for large-scale in vivo screening, based on validated morphological or molecular markers and behavioral responses...
Molecular & biochemical
Sample preparation: Genomic DNA preparation, Total RNA extraction, Proteins extraction...
Histology & Immunohistochemistry
Sample preparation, histological staining, immunohistochemical staining & microscopy.
Rapid in vivo preclinical screening service for the pharmaceutical development of new drug candidates.
Drug discovery: Amylgen's positioning
One of major Amylgen's achievements:
By using its non transgenic mouse model of Alzheimer's disease, Amylgen has been able to bring to Anavex Life Sciences Corp. the proof of concept in vivo of the efficacy of ANAVEX 2-73, its lead compound for the treatment of Alzheimer's disease. Phase 1 single ascending dose (SAD) clinical trial has successfully been completed and a multiple ascending dose trial is ongoing.