/// Scopolamine-induced cognitive impairments
One of the mechanisms thought to play a role in dementia involves the forebrain acetylcholine system. Pharmacological blockade of muscarinic acetylcholine receptors in the brain results in a variety of effects on cognitive functions. Because of global impairment and neurochemical correspondence with Alzheimer’s disease scopolamine administration may be an attractive model of cognitive decline.
/// Dizocilpine-induced cognitive deficit
Dizocilpine (MK-801) is a non-competitive antagonist of the N-Methyl-D- aspartate (NMDA) type of glutamate receptor. Dizocilpine blocks NMDA receptors, at the PCP site, in a use- and voltage-dependent manner. It acts as a potent anti-convulsant and dissociative anesthetic, but also induces learning impairments, cognitive disruption and psychotomimetic reactions.