Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25-35 peptide-injected mice, a nontransgenic Alzheimer’s disease model

  Authors: Lahmy V1, Long R2, Morin D2, Villard V3, Maurice T1 1Inserm U 710, University of Montpellier 2 Montpellier, France ; Amylgen, Montferrier-sur-Lez France. 2Inserm […]

The Effects of Sigma-1 Receptor Selective Ligands on Muscarinic Receptor Antagonist Induced Cognitive Deficits in Mice

  Authors: Malik M1, Rangel-Barajas C, Sumien N, Su C, Singh M, Chen Z, Huang RQ, Meunier J, Maurice T, Mach RH, Luedtke RR. 1University of North […]

Combining two repurposed drugs as a promising approach for Alzheimer’s disease therapy.

Authors: Ilya Chumakov1, Serguei Nabirotchkin1, Nathalie Cholet1, Aude Milet1, Aurélie Boucard1, Damien Toulorge1, Yannick Pereira1, Esther Graudens1, Sory Traoré1, Julie Foucquier1, Mickael Guedj1, Emmanuel Vial1, Noëlle […]

Brain Toxicity and Inflammation Induced In Vivo in Mice by the Amyloid-β Forty-Two Inducer Aftin-4, a Roscovitine Derivative

  Authors: Meunier J1, Borjini N1, Gillis C1, Villard V1, Maurice T2. 1Amylgen, Montferrier-sur-Lez, France. 2Amylgen, Montferrier-sur-Lez, France INSERM U. 710, University of Montpellier 2, Montpellier, France. […]

Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice.

  Authors: Detrait ER, Danis B, Lamberty Y, Foerch P.   Abstract: Alzheimer’s disease has long been associated with increased inflammation in the brain. Activated microglia […]

Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ25-35 peptide-induced toxicity in vitro and in vivo in mice.

  Authors: El Bitar F1, Meunier J, Villard V, Alméras M, Krishnan K, Covey DF, Maurice T, Akwa Y.   Abstract: Rational > Pregnenolone sulfate (PREGS) […]

Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Aβ₂₅₋₃₅ non-transgenic mouse model of Alzheimer’s disease.

  Authors: Maurice T, Mustafa MH, Desrumaux C, Keller E, Naert G de la C García-Barceló M, Rodríguez Cruz Y, Garcia Rodríguez JC.   Abstract : […]

Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer’s disease.

  Authors :Lahmy V, Meunier J, Malmström S, Naert G, Givalois L, Kim SH, Villard V, Vamvakides A, Maurice T.   Abstract: The main objective of the […]

Alzheimer’s disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats.

  Authors: Zussy C1, Brureau A, Keller E, Marchal S, Blayo C, Delair B, Ixart G, Maurice T, Givalois L.   Abstract: Alzheimer’s disease (AD) is […]

Deregulation of hypothalamic-pituitary-adrenal axis functions in an Alzheimer’s disease rat model.

  Authors: Brureau A1, Zussy C, Delair B, Ogier C, Ixart G, Maurice T, Givalois L.   Abstract: Elevated cortisol evidence in Alzheimer’s disease (AD) patients […]

Increased amyloid-β peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice.

  Authors: Desrumaux C, Pisoni A, Meunier J, Deckert V, Athias A, Perrier V, Villard V, Lagrost L, Verdier JM, Maurice T.   Abstract :Oxidative stress […]

The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer’s disease.

  Authors :  Meunier J1, Villard V, Givalois L, Maurice T   Abstract :  Alzheimer’s disease pathomimetic toxicity could be induced in mice within one week after […]

Peripheral anti- TNF treatment reduces TNF levels in hippocampus and counteracts amyloid-induced working and long-term memory deficits in mice.

  Authors: E.R DETRAIT, B. DANIS, P. FOERCH, Y. LAMBERTY; UCB pharma S.A., Braine-L’Alleud, Belgium.   Abstract: Alzheimer disease has long been associated with increased inflammation […]

Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea.

  Authors: Menardo J1, Tang Y, Ladrech S, Lenoir M, Casas F, Michel C, Bourien J, Ruel J, Rebillard G, Maurice T, Puel JL, Wang J. […]

Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants.

  Authors: Villard V, Meunier J, Chevallier N, Maurice T.   Abstract: Selective agonists of the sigma-1 (σ(1)) ligand-operated chaperone protein, like igmesine or PRE-084, are […]

Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats.

  Authors: Zussy C, Brureau A, Delair B, Marchal S, Keller E, Ixart G, Naert G, Meunier J, Chevallier N, Maurice T, Givalois L.   Abstract: […]

Behavioural phenotyping of knockout mice for the sigma-1 (σ₁) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations.

  Authors: Chevallier N, Keller E, Maurice T.   Abstract: The sigma-1 (σ₁) protein regulates calcium homeostasis and acts as an endoplasmic reticulum chaperone. It can […]

Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative.

  Authors: Villard V, Espallergues J, Keller E, Vamvakides A, Maurice T.   Abstract: Tetrahydro-N, N-dimethyl-2, 2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) binds to muscarinic acetylcholine and sigma(1) (σ(1)) […]