Neuroprotective effect of a new photobiomodulation technique against Aβ25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer’s disease suggested

Amylgen’s murine model demonstrates the efficacy of RegenLife ’s device application for the treatment of Alzheimer’s disease   Regenlife is opening doors to new treatment options for Alzheimer’s […]

Amylgen’s murine model demonstrates the efficacy of RegenLife ’s device application for the treatment of Alzheimer’s disease

Regenlife is opening doors to new treatment options for Alzheimer’s disease. Read the original article here.      

Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25-35 peptide-injected mice, a nontransgenic Alzheimer’s disease model

  Authors: Lahmy V1, Long R2, Morin D2, Villard V3, Maurice T1 1Inserm U 710, University of Montpellier 2 Montpellier, France ; Amylgen, Montferrier-sur-Lez France. 2Inserm […]

The Effects of Sigma-1 Receptor Selective Ligands on Muscarinic Receptor Antagonist Induced Cognitive Deficits in Mice

  Authors: Malik M1, Rangel-Barajas C, Sumien N, Su C, Singh M, Chen Z, Huang RQ, Meunier J, Maurice T, Mach RH, Luedtke RR. 1University of North […]

Combining two repurposed drugs as a promising approach for Alzheimer’s disease therapy.

Authors: Ilya Chumakov1, Serguei Nabirotchkin1, Nathalie Cholet1, Aude Milet1, Aurélie Boucard1, Damien Toulorge1, Yannick Pereira1, Esther Graudens1, Sory Traoré1, Julie Foucquier1, Mickael Guedj1, Emmanuel Vial1, Noëlle […]

Brain Toxicity and Inflammation Induced In Vivo in Mice by the Amyloid-β Forty-Two Inducer Aftin-4, a Roscovitine Derivative

  Authors: Meunier J1, Borjini N1, Gillis C1, Villard V1, Maurice T2. 1Amylgen, Montferrier-sur-Lez, France. 2Amylgen, Montferrier-sur-Lez, France INSERM U. 710, University of Montpellier 2, Montpellier, France. […]

Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice.

  Authors: Detrait ER, Danis B, Lamberty Y, Foerch P.   Abstract: Alzheimer’s disease has long been associated with increased inflammation in the brain. Activated microglia […]

Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ25-35 peptide-induced toxicity in vitro and in vivo in mice.

  Authors: El Bitar F1, Meunier J, Villard V, Alméras M, Krishnan K, Covey DF, Maurice T, Akwa Y.   Abstract: Rational > Pregnenolone sulfate (PREGS) […]

Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Aβ₂₅₋₃₅ non-transgenic mouse model of Alzheimer’s disease.

  Authors: Maurice T, Mustafa MH, Desrumaux C, Keller E, Naert G de la C García-Barceló M, Rodríguez Cruz Y, Garcia Rodríguez JC.   Abstract : […]

Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer’s disease.

  Authors :Lahmy V, Meunier J, Malmström S, Naert G, Givalois L, Kim SH, Villard V, Vamvakides A, Maurice T.   Abstract: The main objective of the […]

Alzheimer’s disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats.

  Authors: Zussy C1, Brureau A, Keller E, Marchal S, Blayo C, Delair B, Ixart G, Maurice T, Givalois L.   Abstract: Alzheimer’s disease (AD) is […]

Deregulation of hypothalamic-pituitary-adrenal axis functions in an Alzheimer’s disease rat model.

  Authors: Brureau A1, Zussy C, Delair B, Ogier C, Ixart G, Maurice T, Givalois L.   Abstract: Elevated cortisol evidence in Alzheimer’s disease (AD) patients […]

Increased amyloid-β peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice.

  Authors: Desrumaux C, Pisoni A, Meunier J, Deckert V, Athias A, Perrier V, Villard V, Lagrost L, Verdier JM, Maurice T.   Abstract :Oxidative stress […]

The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer’s disease.

  Authors :  Meunier J1, Villard V, Givalois L, Maurice T   Abstract :  Alzheimer’s disease pathomimetic toxicity could be induced in mice within one week after […]

Peripheral anti- TNF treatment reduces TNF levels in hippocampus and counteracts amyloid-induced working and long-term memory deficits in mice.

  Authors: E.R DETRAIT, B. DANIS, P. FOERCH, Y. LAMBERTY; UCB pharma S.A., Braine-L’Alleud, Belgium.   Abstract: Alzheimer disease has long been associated with increased inflammation […]

Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea.

  Authors: Menardo J1, Tang Y, Ladrech S, Lenoir M, Casas F, Michel C, Bourien J, Ruel J, Rebillard G, Maurice T, Puel JL, Wang J. […]

Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants.

  Authors: Villard V, Meunier J, Chevallier N, Maurice T.   Abstract: Selective agonists of the sigma-1 (σ(1)) ligand-operated chaperone protein, like igmesine or PRE-084, are […]

Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats.

  Authors: Zussy C, Brureau A, Delair B, Marchal S, Keller E, Ixart G, Naert G, Meunier J, Chevallier N, Maurice T, Givalois L.   Abstract: […]

Behavioural phenotyping of knockout mice for the sigma-1 (σ₁) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations.

  Authors: Chevallier N, Keller E, Maurice T.   Abstract: The sigma-1 (σ₁) protein regulates calcium homeostasis and acts as an endoplasmic reticulum chaperone. It can […]

Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative.

  Authors: Villard V, Espallergues J, Keller E, Vamvakides A, Maurice T.   Abstract: Tetrahydro-N, N-dimethyl-2, 2-diphenyl-3-furanmethanamine hydrochloride (ANAVEX2-73) binds to muscarinic acetylcholine and sigma(1) (σ(1)) […]